abstract：:Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...

journal_title：Life sciences

authors： Zhao S,Chu Y,Zhang Y,Zhou Y,Jiang Z,Wang Z,Mao L,Li K,Sun W,Li P,Jia S,Wang C,Xu A,Loomes K,Tang S,Wu D,Hui X,Nie T

更新日期：2019-04-01 00:00:00

abstract：AIMS:Obesity is associated with increased cardiovascular morbidity and mortality. It is accompanied by augmented O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins via increasing hexosamine biosynthetic pathway (HBP) flux. However, the changes and regulation of the O-GlcNAc levels induced by obesity are...

journal_title：Life sciences

authors： Cui YL,Xue RQ,Xi He,Ming Zhao,Yu XJ,Liu LZ,Wu Q,Si Yang,Li DL,Zang WJ

更新日期：2019-04-01 00:00:00

abstract：AIMS:The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism. MAIN METHODS:Diabetes w...

journal_title：Life sciences

authors： Zha D,Yao T,Bao L,Gao P,Wu X

更新日期：2019-03-15 00:00:00

abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...

journal_title：Life sciences

authors： Li W,Dong M,Guo P,Liu Y,Jing Y,Chen R,Zhang M

更新日期：2019-03-15 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:The human eye being a complex and a very sensitive organ makes the drug delivery task challenging. An increase in the intra-ocular pressure at the aqueous humour leads to glaucoma which is not only indecipherable but can also be the reason of blindness for many. The presently available marketed formulations using anti...

journal_title：Life sciences

authors： Yadav KS,Rajpurohit R,Sharma S

更新日期：2019-03-15 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：OBJECTIVE:To explore the correlation of the viscus fat area (VFA) with the Framingham 10-year general cardiovascular disease risk in patients with type 2 diabetes mellitus (T2DM). METHODS:A total of 202 patients with T2DM were divided into two groups based on VFA (a VFA ≥ 100 cm2 group and a VFA < 100 cm2 group), or f...

journal_title：Life sciences

authors： Xu L,Song P,Xu J,Zhang H,Yu C,Guan Q,Zhao M,Zhang X

更新日期：2019-03-01 00:00:00

abstract：AIMS:This study aims to develop and evaluate oleuropein loaded surface functionalized folate-targeted - PEG liposomes for the effective management of prostate cancer in an animal model. MATERIALS AND METHODS:Film hydration-cum-extrusion technique was used to produce liposomes. Particle size, entrapment efficiency, dru...

journal_title：Life sciences

authors： Nassir AM,Ibrahim IAA,Md S,Waris M,Tanuja,Ain MR,Ahmad I,Shahzad N

更新日期：2019-03-01 00:00:00

abstract：AIMS:The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential roles in intercellular crosstalk. Here, it is proposed that tumor cell-derived exosomes could function as vehicles to deliver exogenous miRNA-155 into DCs, f...

journal_title：Life sciences

authors： Asadirad A,Hashemi SM,Baghaei K,Ghanbarian H,Mortaz E,Zali MR,Amani D

更新日期：2019-02-15 00:00:00

abstract：:Thirty-four novel, diaryl ω-(isothiocyanato)alkylphosphonates with chlorine atom and methoxy, dimethoxy, methylsulfanyl, or methoxycarbonyl groups at ortho, meta, or para positions of the phenyl ring, and with an unbranched alkyl chain (n = 2-6) were designed and synthesized in a one-pot reaction in 11-76% yields. All...

journal_title：Life sciences

authors： Janczewski Ł,Burchacka E,Psurski M,Ciekot J,Gajda A,Gajda T

更新日期：2019-02-15 00:00:00

abstract：:Insulin remains a predominant life-saving medication for type 1 and type 2 Diabetes Mellites. Natural insulin secretion limits the fluctuation of the narrow and high surge of blood glucose levels. However, imitating the same by external insulin remains a challenge as a variety of insulin analogs (rapid acting, short a...

journal_title：Life sciences

authors： Sharma AK,Taneja G,Kumar A,Sahu M,Sharma G,Kumar A,Sardana S,Deep A

更新日期：2019-02-15 00:00:00

abstract：:Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATE...

journal_title：Life sciences

authors： Ma Z,Bao X,Gu J

更新日期：2019-02-01 00:00:00

abstract：:This review aims to systematically review and synthesize scientific evidence for the influence of air pollution exposure and outdoor exercise on health. We conducted a literature search in the PubMed, Cochrane, EMBASE, and Web of Science for articles that evaluated the combination effect of air pollution exposure and ...

journal_title：Life sciences

authors： Qin F,Yang Y,Wang ST,Dong YN,Xu MX,Wang ZW,Zhao JX

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...

journal_title：Life sciences

authors： Ma Z,Dong Q,Lyu B,Wang J,Quan Y,Gong S

更新日期：2019-02-01 00:00:00

abstract：:Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and pathogenesis, all have the same tar...

journal_title：Life sciences

authors： Salas-Silva S,Simoni-Nieves A,Lopez-Ramirez J,Bucio L,Gómez-Quiroz LE,Gutiérrez-Ruiz MC,Roma MG

更新日期：2019-02-01 00:00:00

abstract：AIMS:We sought to reveal the key molecular signature in subcutaneous adipose tissue (scAT) following Roux-en-Y gastric bypass (RYGB), through bioinformatics analysis and further verification in vivo. MAIN METHODS:We obtained a transcriptome data of scAT from RYGB and sham-operated rats from the Gene Expression Omnibus...

journal_title：Life sciences

authors： Chen X,Gong L,Li Q,Hu J,Liu X,Wang Y,Bai J,Ran X,Wu J,Ge Q,Li R,Xiao X,Li X,Zhang J,Wang Z

更新日期：2019-02-01 00:00:00

abstract：:This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiratio...

journal_title：Life sciences

authors： Szereda-Przestaszewska M,Kaczyńska K

更新日期：2019-01-15 00:00:00

abstract：:The complexes of the type [PtCl(L2)(ACRAMTU)](NO3)2 (ACRAMTU = 1-[2-(acridin-9-ylamino)ethyl]-1,3-dimethylthiourea) were synthesized: PT-ACRAMTU (1), L2 = ethane-1,2-diamine (en); PT(dach)-ACRAMTU (2), L2 = (1R,2R)-1,2-diaminocyclohexane (dach); PT(pda-OH)-ACRAMTU (3), L2 = 2-hydroxy-1,3-propanediamine (pda-OH). The c...

journal_title：Life sciences

authors： Zhou Q,You C,Ling Y,Wu H,Sun B

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...

journal_title：Life sciences

authors： Lei Y,Peng X,Li T,Liu L,Yang G

更新日期：2019-01-01 00:00:00

abstract：AIMS:Inducible nitric oxide synthase (iNOS) pathway has been in the limelight since its discovery as a key mediator in the process of liver fibrogenesis. Therefore, the objective of the current study was to elucidate the in vivo molecular mechanism underlying the hepatic preventive relevance of eugenol (EUG) and telmis...

journal_title：Life sciences

authors： Fathy M,Khalifa EMMA,Fawzy MA

更新日期：2019-01-01 00:00:00

abstract：AIMS:The roles of miR-141 in various types of cancers and inflammatory bowel diseases are researched, whereas, little information about its function in lung inflammation is available. This study was designed to explore the effect of miR-141 on inflammation injury in WI-38 cells, possibly providing basis for targeted th...

journal_title：Life sciences

authors： Quan B,Zhang H,Xue R

更新日期：2019-01-01 00:00:00

abstract：:Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflamm...

journal_title：Life sciences

authors： Figliuolo VR,Coutinho-Silva R,Coutinho CMLM

更新日期：2018-12-15 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the ...

journal_title：Life sciences

authors： Duerr GD,Feißt A,Halbach K,Verfuerth L,Gestrich C,Wenzel D,Zimmer A,Breuer J,Dewald O

更新日期：2018-12-15 00:00:00

abstract：AIMS:Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. MAIN METHODS:Expression of NRSF in n...

journal_title：Life sciences

authors： Deng P,Zuo Y,Feng S,Li Z,Chen W,Li H,Wang X

更新日期：2018-12-15 00:00:00

abstract：:Matrikines, peptides originating from the fragmentation of extracellular matrix proteins are identified to play important role in both health and disease. They possess biological activities, much different from their parent protein. Identification of such bioactive cryptic regions in the extracellular matrix proteins ...

journal_title：Life sciences

authors： Sivaraman K,Shanthi C

更新日期：2018-12-01 00:00:00

abstract：:Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...

journal_title：Life sciences

authors： Rahmani S,Pour Khalili N,Khan F,Hassani S,Ghafour-Boroujerdi E,Abdollahi M

更新日期：2018-12-01 00:00:00

abstract：AIMS:Macrophage-derived foam-cell formation plays a crucial role in the development of atherosclerosis, and liver X receptor alpha (LXRα) is a key regulator of lipid metabolism in macrophages. Homocysteine (Hcy) is an independent risk factor of atherosclerosis; however, the regulation of lipid metabolism and role of LX...

journal_title：Life sciences

authors： Jin P,Bian Y,Wang K,Cong G,Yan R,Sha Y,Ma X,Zhou J,Yuan Z,Jia S

更新日期：2018-12-01 00:00:00

abstract：AIMS:Ischemia-reperfusion injury is one of the most common cardiac disorders leading to irreversible heart damage. Many underlying mechanisms seem to be involved, among which mitochondrial dysfunction. Since physical training has a beneficial effect on mitochondrial dynamics (fusion and fission), it may have a cardiopr...

journal_title：Life sciences

authors： Ghahremani R,Damirchi A,Salehi I,Komaki A,Esposito F

更新日期：2018-11-15 00:00:00

abstract：AIMS:To study the underlying mechanisms of sulforaphane, a natural histone deacetylase (HDAC) inhibitor, in inhibiting triple negative breast cancer cells growth and the therapeutic effects of combination of sulforaphane and doxorubicin in TNBC treatment. MATERIALS AND METHODS:The antineoplastic activity of sulforapha...

journal_title：Life sciences

authors： Yang F,Wang F,Liu Y,Wang S,Li X,Huang Y,Xia Y,Cao C

更新日期：2018-11-15 00:00:00

abstract：AIMS:Toxoplasma gondii (T. gondii) is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. Its parasitic invasion leads to encephalitis, uveitis, chorioretinitis and congenital infection. Host invasion by T. gondii is mediated by Moving junction (MJ) complex formed by secretory protei...

journal_title：Life sciences

authors： Vetrivel U,Nagarajan H

更新日期：2018-11-15 00:00:00

abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...

journal_title：Life sciences

authors： Liu J,Xu Y,Wu Q,Ding Q,Fan W

更新日期：2018-11-01 00:00:00

abstract：:In this study we examined if sleep time, caloric intake and energy expenditure are important contributors to development of ovariectomy-induced obesity in mice fed control or high fat diet (HFD). Twelve female mice at 6 weeks of age were divided into 2 groups: Sham (n = 5) and ovariectomized (OVX, n = 7). Mice were fe...

journal_title：Life sciences

authors： do Carmo JM,da Silva AA,Moak SP,Browning JR,Dai X,Hall JE

更新日期：2018-11-01 00:00:00

abstract：AIM:The objective of this study was to investigate the potential of aerobic exercise training (AET) to prevent kidney lipid accumulation and the contribution of renal metabolism to mediate this response. MAIN METHODS:Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 13), CHOW-TR (chow di...

journal_title：Life sciences

authors： Muller CR,Américo ALV,Fiorino P,Evangelista FS

更新日期：2018-10-15 00:00:00

abstract：:Liver fibrosis is a global health issue that causes morbidity and mortality with no currently available treatment. It has been shown that low dose paclitaxel (PTX) can stabilize microtubules and inhibit the profibrotic transforming growth factor-beta 1 (TGF-β1) signaling pathway. In this study the effect of treatment ...

journal_title：Life sciences

authors： Sharawy MH,Abdel-Rahman N,Megahed N,El-Awady MS

更新日期：2018-10-15 00:00:00

abstract：AIMS:The aims of this study were to evaluate the effects of p62/SQSTM1 expression levels on lipopolysaccharide (LPS)-induced mucus secretion in BEAS-2B bronchial epithelial cells by measuring expression levels of the MUC5AC gene and the Mucin-5AC (MUC5AC) protein. MATERIALS AND METHODS:Bronchial epithelial cells, BEAS...

journal_title：Life sciences

authors： Wu Y,Li Y,Wang B,He X,Li Y,Wu B,Yu G,Wang H,Xu B

更新日期：2018-10-15 00:00:00

abstract：:The lymphatic vessels have been implicated in maintenance of interstitial fluid homeostasis and immune responses, and pathological conditions including inflammation, wound healing, lymphedema and tumor progression. The knowledge about the lymphatic structure and function in muscles, especially in muscular disorders, r...

journal_title：Life sciences

authors： Ji RC

更新日期：2018-10-15 00:00:00

abstract：AIMS:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inf...

journal_title：Life sciences

authors： Chen L,Li W,Qi D,Lu L,Zhang Z,Wang D

更新日期：2018-10-01 00:00:00

abstract：AIM:Epidermal growth factor receptor (EGFR) related reactive oxygen species (ROS) generation results in myocardial damage. We aimed to investigate the role of gefitinib (EGFR-tyrosine kinase inhibitor) in diabetic cardiomyopathy (DbCM). METHOD:DbCM was induced by injecting streptozotocin (55 mg/kg for 5 consecutive da...

journal_title：Life sciences

authors： Shah S,Akhtar MS,Hassan MQ,Akhtar M,Paudel YN,Najmi AK

更新日期：2018-10-01 00:00:00